A Kinase Anchor Protein-12
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A Kinase Anchor Protein-12 Definition
Encoded by human AKAP12 Gene, A Kinase Anchor Protein 12 is expressed in endothelial cells, but not in platelets or peripheral blood cells. The 1,781-amino acid 191 kD cytoplasmic anchoring protein appears to mediate compartmentation of PKA and PKC in the cortical cytoskeleton. Its amphipathic alpha helix binds to the PKA RII subunit and tethers the enzyme near its substrates. Activated by lysopc, AKAP12 inhibits PKC. Polybasic regions are involved in binding PKC. (OMIM, Swiss-Prot, and NCI)
A Kinase Anchor Protein-12 Synonyms
A Kinase Anchor Protein 12, A Kinase (PRKA) Anchor Protein 12, A-Kinase Anchor Protein, 250-kD, AKAP12, AKAP250, Gravin, Myasthenia Gravis Autoantigen Gravin Protein
Terms in A Kinase Anchor Protein-12 category
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