AHR Signal Transduction Pathway
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AHR Signal Transduction Pathway Definition
The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ahreceptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also refered to as AIP or ARA9). (BioCarta)
AHR Signal Transduction Pathway Synonyms
AHR Signal Transduction Pathway, Ahr Signal Transduction Pathway
Terms in AHR Signal Transduction Pathway category
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