AML1-ETO Chimeric Protein
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AML1-ETO Chimeric Protein Definition
In acute myeloid leukemia, the frequent t(8;21)(q22;q22) translocation produces a chimeric AML1/ETO gene. Association of the AML1/ETO product with the NCOR/HDAC complex blocks hematopoietic differentiation. The interaction requires ETO coiled-coil regions and is responsible for abnormal recruitment of NCOR, transcriptional repression, and impaired differentiation of primary hematopoietic precursors. AML1/ETO transcripts are present in a fraction of stem cells, monocytes, marrow B-cells, and in colony-forming cells of erythroid, granulocyte-macrophage, and/or megakaryocyte lineages, but not in T-cells. (from OMIM 133435 and NCI)
AML1-ETO Chimeric Protein Synonyms
AML-1/ETO, Acute Myeloid Leukemia-1/Eight-Twenty-One Protein
Terms in AML1-ETO Chimeric Protein category
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