Adenosine A3 Receptor Agonist CF102
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Adenosine A3 Receptor Agonist CF102 Definition
An orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Adenosine A3 receptor agonist CF102 selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.
Adenosine A3 Receptor Agonist CF102 Synonyms
Adenosine A3 Receptor Agonist CF102, 2-Chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide, 2-Cl-IB-MECA, A3AdR Agonist CF102, Adenosine Receptor A3 Agonist CF102, C-Ibza-MU, CF102
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