Aliskiren

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Cardiovascular System -> Antihypertensive Agent -> Aliskiren

Aliskiren Definition

An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in the renin-angiotensin-aldosterone system (RAAS) that is responsible for converting angiotensinogen to angiotensin I (AT I). By inhibiting the activity of renin, the conversion to AT I is prevented, which in turn prevents the conversion of AT I to AT II. This prevents arterial vasoconstriction by AT II and inhibits the production of aldosterone by AT II. As aldosterone causes re-uptake of sodium and water and eventually an increase in extracellular volume, aliskiren is able to prevent the effects that contribute to an increase in blood pressure.

Aliskiren Synonyms

Aliskiren, (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl)-2-methylpropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonamide, ALISKIREN, CGP 60536, SPP100, Tekturna

Aliskiren

Aliskiren Definition

Aliskiren Synonyms

Terms in Aliskiren category