Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968
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Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968 Definition
A synthetic antisense oligodeoxynucleotide (ODN) targeting hypoxia-inducible factor-1alpha (HIF-1alpha) with potential antineoplastic activity. Anti-HIF-1alpha LNA antisense oligonucleotide EZN-2968 hybridizes with HIF-1alpha mRNA and blocks t HIF-1 alpha protein expression, which may result in the inhibition of angiogenesis, the inhibition of tumor cell proliferation, and apoptosis. HIF-1alpha, normally activated in response to hypoxia-induced stress, is a key transcription regulator of a large number of genes important in cellular adaptation to low-oxygen conditions, including angiogenesis, cell proliferation, apoptosis, and cell invasion.
Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968 Synonyms
Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968, EZN-2968, anti-HIF-1alpha LNA AS-ODN
Terms in Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968 category
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