Anti-IL-6 Chimeric Monoclonal Antibody
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Agent ->
Monoclonal Antibody -> Anti-IL-6 Chimeric Monoclonal Antibody
Anti-IL-6 Chimeric Monoclonal Antibody Definition
A human-mouse chimeric antibody, constructed from a murine anti-interleukin 6 (IL-6) monoclonal antibody, with antitumor and anti-inflammatory activities. Containing the antigen-binding variable region of the murine antibody, CLB-IL-6-8, and the constant region of a human IgG1kappa immunoglobulin, anti-IL-6 chimeric monoclonal antibody has high affinity for recombinant as well as native IL-6 and inhibits the binding of IL-6 to the IL-6 receptor (IL-6R), resulting in the blockade of the IL-6/IL-6R/gp130 signal transduction pathway, and, subsequently, antitumor and anti-inflammatory activities.
Anti-IL-6 Chimeric Monoclonal Antibody Synonyms
Anti-IL-6 Chimeric Monoclonal Antibody, CNTO-328, cCLB8
Terms in Anti-IL-6 Chimeric Monoclonal Antibody category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.