Anti-PD-1 Human Monoclonal Antibody MDX-1106
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Agent ->
Monoclonal Antibody -> Anti-PD-1 Human Monoclonal Antibody MDX-1106
Anti-PD-1 Human Monoclonal Antibody MDX-1106 Definition
A fully human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1/PCD-1) with immunopotentiation activity. Anti-PD-1 human monoclonal antibody MDX-1106 binds to and blocks the activation of PD-1, an Ig superfamily transmembrane protein, by its ligands PD-L1 and PD-L2, resulting in the activation of T-cells and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and effector function through the suppression of P13k/Akt pathway activation.
Anti-PD-1 Human Monoclonal Antibody MDX-1106 Synonyms
Anti-PD-1 Human Monoclonal Antibody MDX-1106, MDX-1106, ONO-4538
Terms in Anti-PD-1 Human Monoclonal Antibody MDX-1106 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.