Apoptosis Inducer GMX1777
-> Drugs and Chemicals
-> Pharmacologic Substance
-> Antineoplastic Agent
-> Apoptosis Inducer GMX1777
Apoptosis Inducer GMX1777 Definition
A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.
Apoptosis Inducer GMX1777 Synonyms
Teglarinad Chloride, CHS828 Prodrug, EB1627, GMX1777, Pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride
Terms in Apoptosis Inducer GMX1777 category
No reproduction or republication permitted.