Cancer Terms

Apoptosis Inducer GMX1777

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Apoptosis Inducer GMX1777

Apoptosis Inducer GMX1777 Definition

A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.

Apoptosis Inducer GMX1777 Synonyms

Teglarinad Chloride, CHS828 Prodrug, EB1627, GMX1777, Pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride

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