Axin-2 Protein
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Axin-2 Protein Definition
Axin 2 protein is presumed to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. The deregulation of beta-catenin is an apparent important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. (from Locus Link)
Axin-2 Protein Synonyms
Axin 2, AXIN2, Axil, Axis Inhibitor 2, Conductin
Terms in Axin-2 Protein category
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