Bispecific Antibody 520C9XH22
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Bispecific Antibody 520C9XH22 Definition
A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu-overexpressing tumor cells with potential antineoplastic activity. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody 520C9 and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody H22. This agent selectively binds to both HER2/neu-expressing tumor cells and Fc gammaRI-expressing cytotoxic effector cells, which may trigger antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis of HER2/neu-expressing tumor cells. While HER2/neu is overexpressed in a variety of epithelial malignancies, expression of Fc gammaRI is primarily found in cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells.
Bispecific Antibody 520C9XH22 Synonyms
Bispecific Antibody MDX-H210, 520C9x22 Bispecific Antibody, 520C9xH22 Bispecific Antibody, Antibody, Bispecific 520C9xH22, Bispecific Antibody 520C9 x H22, Bispecific Antibody MDXH210, BsAb 520C9x22, BsAb 520C9xH22, MDX-210, MDX-H210
Terms in Bispecific Antibody 520C9XH22 category
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