CYP2D6 4 Allele
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CYP2D6 4 Allele Definition
Human CYP2D6*4 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*4 protein. The CYP2D6*4 allele exhibits a clinically-relevant SNP (g.1846G>A) at the consensus sequence of the splice site of intron 3 that results in a premature stop codon. This alteration yields a truncated cytochrome P450 2D6*4 protein that is enzymatically inactive.
CYP2D6 4 Allele Synonyms
CYP2D6*4 Allele, CYP2D6(B), CYP2D6*4, CYP2D6, K29-1, CYP2D6, g.1846G>A, CYP2D6B, Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*4 Allele
Terms in CYP2D6 4 Allele category
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