CYP2E1 1 Allele
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CYP2E1 1 Allele Definition
Human CYP2E1*1 allele is located within 10q24.3-qter and is approximately 12 kb in length. This allele, a variant form of the CYP2E1 wild-type allele, encodes cytochrome P450 2E1*1 protein. The CYP2E1*1 allele contains 6 to 8 repeats of cis-acting elements (each 42-60 bp long) in the 5'-flanking region of the gene. This repeat polymorphism results in increased enzymatic activity of the cytochrome P450 2E1*1 protein in individuals who carry this allele. However, enhanced in vivo enzymatic activity is only detected after alcohol consumption or in obese individuals.
CYP2E1 1 Allele Synonyms
CYP2E1*1 Allele, CYP2E1*1, Cytochrome P450, Family 2, Subfamily E, Polypeptide 1*1 Allele
Terms in CYP2E1 1 Allele category
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