CYP3A5 6 Allele
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CYP3A5 6 Allele Definition
Human CYP3A5*6 allele is located in the vicinity of 7q21.1 and is approximately 32 kb in length. This allele, a variant form of the human CYP3A5 wild-type allele, encodes cytochrome P450 3A5*6 protein. The CYP3A5*6 allele exhibits a clinically-relevant SNP (g.14690G>A), resulting in deletion of exon 7 from the splice variant, a frame shift and premature stop at 184 amino acids. Truncation of the cytochrome P450 3A5*6 protein causes complete loss of enzymatic activity.
CYP3A5 6 Allele Synonyms
CYP3A5*6 Allele, CYP3A5*6, CYP3A5, g.14690G>A, Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*6 Allele
Terms in CYP3A5 6 Allele category
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