DNA Damage

Cancer Terms -> Biological Process -> Pathologic Process -> Pathogenesis -> Pathologic Mutagenesis -> DNA Damage

DNA Damage Definition

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.

DNA Damage Synonyms

DNA Damage

Terms in DNA Damage category

Abasic Site Formation
Base-Base Mismatch
DNA Adduction
DNA Crosslinking
DNA Replication Damage
DNA Strand Break