DNA Excision Repair Protein-ERCC2
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
DNA Repair Protein -> DNA Excision Repair Protein-ERCC2
DNA Excision Repair Protein-ERCC2 Definition
Encoded by human ERCC2 Gene (RAD3/XPD Family), 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2 is an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)
DNA Excision Repair Protein-ERCC2 Synonyms
DNA Excision Repair Protein ERCC-2, CXPD, DNA-Repair Protein Complementing XP-D Cells, DNA-Repair Protein XPD, ERCC2, Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 Protein, TFIIH Basal Transcription Factor Complex Helicase Subunit, Xeroderma Pigmentosum Group D Complementing Protein
Terms in DNA Excision Repair Protein-ERCC2 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.