DRD2-A2 Allele

Cancer Terms -> Gene -> Ligand Binding Protein Gene -> Receptor Gene -> G Protein-Coupled Receptor Gene -> DRD2 Gene -> DRD2-A2 Allele

DRD2-A2 Allele Definition

Human DRD2 Gene at 11q23 encodes Dopamine Receptor D2, a G-protein coupled receptor that inhibits adenylyl cyclase activity. Missense mutation in DRD2 causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing results in two different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. Different alleles are associated with increased incidence of substance abuse. (NCI)

DRD2-A2 Allele Synonyms

DRD2 2 Allele, DRD2 A2 Allele, Dopamine Receptor D2 A2 Allele

Terms in DRD2-A2 Allele category

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