Dapsone
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Anti-Infective Agent ->
Sulfone Anti-Infective Agent -> Dapsone
Dapsone Definition
A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.
Dapsone Synonyms
Dapsone, 1358F, 4,4'-Sulfonylbis[benzenamine], 4,4'-Sulfonylbisbenzamine, 4,4'-Sulfonylbisbenzeneamine, 4,4'-Sulfonyldianiline, Aczone, Avlosulfon, Bis(4-aminophenyl) sulfone, Bis(4-aminophenyl)sulfone, Croysulfone, DADPS, DAPSONE, DDS, Diphenasone, Disulone, Dumitone, Eporal, Novophone, Sulfona-MAE, Sulfona-Mae, Sulphadione, Undolac
Terms in Dapsone category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.