Distamycin Antibiotic

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antineoplastic Antibiotic -> Distamycin Antibiotic

Distamycin Antibiotic Definition

A class of oligopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription. In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities. (NCI04)

Distamycin Antibiotic Synonyms

Distamycin Antineoplastic Antibiotic, Distamycins

Terms in Distamycin Antibiotic category

Suradista