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EFP Cell Cycle Pathway

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EFP Cell Cycle Pathway Definition

The estrogen-inducible RING finger protein Efp stimulates proliferation of breast cancer cells. 14-3-3 is p53-inducible protein that sequesters mitotic Cdks in the cytoplasm to inhibit entry into mitosis. To allow cell-cycle progression, estrogens stimulate production of Efp, which binds and ubiquinates 14-3-3s sigma. 14-3-3s marked with ubiquitin chains is recognized and destroyed by the proteosome. Released Cdks are now free to escape into the nucleus and promote mitotic entry.

EFP Cell Cycle Pathway Synonyms

EFP Cell Cycle Pathway, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth

Terms in EFP Cell Cycle Pathway category

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