EWS-FLI1 Type 8
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EWS-FLI1 Type 8 Definition
An antisense oligonucleotide that targets the type 8 form of EWS/FLI-1, an oncogenic fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumor that results from a t(11;22) chromosomal translocation. EWS/FLI 1 type 8 antisense oligonucleotide inhibits the expression of the EWS/FLI 1 type 8 gene and/or the translation of EWS/FLI 1 type 8 mRNA, thereby down-regulating the abnormal transcription factor and inhibiting tumor cell growth and tumorigenicity. (NCI04)
EWS-FLI1 Type 8 Synonyms
EWS/FLI 1 Type 8, Sarcoma-specific Peptide SSSYGQQN/PYQILGPTSS
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