Cancer Terms

Experimental Allergic Encephalomyelitis

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Experimental Allergic Encephalomyelitis Definition

An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenised brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis. --2004

Experimental Allergic Encephalomyelitis Synonyms

Experimental Allergic Encephalomyelitis, EAE

Terms in Experimental Allergic Encephalomyelitis category



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