Folate Antagonist

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antimetabolite -> Folate Antagonist

Folate Antagonist Definition

Compounds with chemical structures similar to folic acid, a key component in cell proliferation, which interfere with folic acid metabolism. Folate antagonists inhibit one or more folate-dependent enzymes, resulting in decreased DNA, RNA and protein synthesis. (NCI)

Folate Antagonist Synonyms

Folate Antagonist, Antifolates, Folate Analog, Folate Inhibitors, Folic Acid Analog, Folic Acid Antagonist, Folic Acid Antagonists, Folic Acid Inhibitors, antifolate, folate antagonist

Terms in Folate Antagonist category

Denopterin
Ketotrexate
M-Azidopyrimethamine
Pteropterin