Folate Receptor Targeted-Microtubule Destabilizing Agent EC0489
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Tubulin Binding Agent -> Folate Receptor Targeted-Microtubule Destabilizing Agent EC0489
Folate Receptor Targeted-Microtubule Destabilizing Agent EC0489 Definition
A folate receptor-targeting cytotoxic drug conjugate consisting of a folate vitamin analogue linked to a vinca alkaloid microtubule destabilizing agent with potential antineoplastic activity. Mediated through its folate moiety, folate receptor-targeted vinca alkaloid EC0489 delivers the cytotoxic vinca alkaloid moiety directly to cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the vinca alkaloid moiety binds to tubulin and disrupts microtubule assembly-disassembly dynamics, resulting in cell cycle arrest and apoptosis. The relative tumor cell specificity of this agent reduces the toxicity profile of its vinca alkaloid moiety.
Folate Receptor Targeted-Microtubule Destabilizing Agent EC0489 Synonyms
Folate Receptor-Targeted Vinca Alkaloid EC0489, EC0489
Terms in Folate Receptor Targeted-Microtubule Destabilizing Agent EC0489 category
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