Fulvestrant
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Fulvestrant Definition
A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)
Fulvestrant Synonyms
Fulvestrant, "Faslodex (Fulvestrant, ICI182780)", 7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol, FULVESTRANT, Faslodex, Faslodex(ICI 182,780), ICI 182,780, ICI 182780, ZD9238
Terms in Fulvestrant category
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