G Protein Pathway Suppressor-2 Protein
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G Protein Pathway Suppressor-2 Protein Definition
Encoded by human GPS2 Gene, 2 isoforms of 327-aa 37-kDa G Protein Pathway Suppressor 2 Protein suppress RAS and MAP kinase signal transduction and interfere with c-JNK activation. GPS2 is an integral subunit of NCOR1/HDAC3 complex. GPS2 and TBL1 in NCOR1/HDAC3 interact with NCOR1 repression domain-1 to link to HDAC3 via the NCOR1 SANT domain, which activates HDAC3 activity. NCOR1/HDAC3 inhibits JNK activation through GPS2. GPS also interacts with E2 and E6 proteins. (NCI)
G Protein Pathway Suppressor-2 Protein Synonyms
G Protein Pathway Suppressor 2 Protein, G Protein Pathway Suppressor 2, G Protein Pathway Suppressor 2 Unknown Protein, GPS2, GPS2 Protein
Terms in G Protein Pathway Suppressor-2 Protein category
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