GW776 5-Fluorouracil-Combination-Tablet
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GW776 5-Fluorouracil-Combination-Tablet Definition
A tablet formulation containing 5-ethynyluracil (GW776), an ethynyl derivative of uracil and the antineoplastic agent 5-Fluorouracil (5-FU) in a 10:1 ratio. The GW776 portion of the tablet inhibits dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in 5-FU catabolism, thereby blocking degradation of 5-FU in the gastrointestinal tract and increasing the bioavailability of 5-FU. (NCI04)
GW776 5-Fluorouracil-Combination-Tablet Synonyms
GW776/5-Fluorouracil Combination Tablet, GW776/5-FU Combination Tablet
Terms in GW776 5-Fluorouracil-Combination-Tablet category
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