Growth-Arrest-Specific Protein-2
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Growth-Arrest-Specific Protein-2 Definition
Widely expressed at growth arrest by human GAS2 Gene, 36-kD Growth-Arrest-Specific Protein 2 is a component of the microfilament system. Localized at the actin cytoskeleton, along stress fibers, and at the plasma membrane, GS2 is phosphorylated on serine residues during G0/G1 transition. Hyperphosphorylated GAS2 accumulates at membrane ruffles. In apoptosis, GAS2 is a substrate for caspases; cleaved forms of GAS2 induce actin cytoskeletal rearrangements and cell shape changes. (NCI)
Growth-Arrest-Specific Protein-2 Synonyms
Growth-Arrest-Specific Protein 2, GAS-2
Terms in Growth-Arrest-Specific Protein-2 category
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