HAP TH-302
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HAP TH-302 Definition
A hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.
HAP TH-302 Synonyms
Hypoxia-Activated Prodrug TH-302, HAP TH-302, TH-302
Terms in HAP TH-302 category
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