Cancer Terms

HAP TH-302

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> HAP TH-302

HAP TH-302 Definition

A hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.

HAP TH-302 Synonyms

Hypoxia-Activated Prodrug TH-302, HAP TH-302, TH-302

Terms in HAP TH-302 category

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