HDAC Inhibitor CRA-024781
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Enzyme Inhibitor ->
Histone Deacetylase Inhibitor -> HDAC Inhibitor CRA-024781
HDAC Inhibitor CRA-024781 Definition
A broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor PCI-24781 inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. In addition, this agent has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51. RAD51, a homologue of bacterial RecA, assists in the repair of DNA double-strand breaks (DSBs).
HDAC Inhibitor CRA-024781 Synonyms
HDAC Inhibitor PCI-24781, CRA-024781, HDAC Inhibitor CRA-024781, PCI-24781
Terms in HDAC Inhibitor CRA-024781 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.