HuCC49deltaCH2-PA-DOTA
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Response Modifier ->
Immunoconjugate ->
Conjugated Mononclonal Antibody CC49 -> HuCC49deltaCH2-PA-DOTA
HuCC49deltaCH2-PA-DOTA Definition
An immunoconjugate comprised of a humanized monoclonal antibody with antitumor activity. The monoclonal antibody CC49 is developed from the murine monoclonal antibody B72.3 and is humanized by grafting the hypervariable regions onto the variable light (VL) and variable heavy (VH) frameworks of the monoclonal antibodies LEN and 21/28' CL. In addition the CH2 domain in the constant region is deleted to increase plasma clearance. The resultant antibody binds to the pancarcinoma tumor-associated glycoprotein (TAG)-72 with high affinity. Furthermore, the antibody is conjugated to PA-DOTA, a bifunctional chelating agent and commonly radiolabeled, resulting in an effective agent for radioimmunotherapy.
HuCC49deltaCH2-PA-DOTA Synonyms
HuCC49deltaCH2-PA-DOTA, HuCC49DCH2-PA-DOTA
Terms in HuCC49deltaCH2-PA-DOTA category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.