IAP Family Gene

Cancer Terms -> Gene -> Apoptosis Regulation Gene -> Apoptosis Inhibitor Gene -> IAP Family Gene

IAP Family Gene Definition

Mammalian IAP Family Genes encode conserved Inhibitors of Apoptosis Proteins with an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)

IAP Family Gene Synonyms

IAP Family Gene

Terms in IAP Family Gene category

BIRC1 Gene
BIRC2 Gene
BIRC3 Gene
BIRC4 Gene
BIRC5 Gene
BIRC6 Gene
BIRC7 Gene