IDEC-114 Monoclonal Antibody

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Agent -> Monoclonal Antibody -> IDEC-114 Monoclonal Antibody

IDEC-114 Monoclonal Antibody Definition

A humanized IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies.

IDEC-114 Monoclonal Antibody Synonyms

Galiximab, GALIXIMAB, IDEC-114, anti-B7-1, anti-CD80 Antibody

Terms in IDEC-114 Monoclonal Antibody category

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