IFN Gamma Signaling Pathway
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IFN Gamma Signaling Pathway Definition
Interferon gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Signaling takes place through an IFN Receptor complex consisting of two alpha chains (type I receptor) and two beta chains (type 2 receptor). Upon phosphorylation by Jak1, Stat1 (alpha) transduces the signal into transcriptional events. (BioCarta)
IFN Gamma Signaling Pathway Synonyms
IFN Gamma Signaling Pathway, IFN gamma signaling pathway
Terms in IFN Gamma Signaling Pathway category
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