Cancer Terms

Ingenol 3-Angelate

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Ingenol 3-Angelate

Ingenol 3-Angelate Definition

A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol 3-angelate (I3A) activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis.

Ingenol 3-Angelate Synonyms

Ingenol 3-Angelate, I3A, PEP005

Terms in Ingenol 3-Angelate category

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