Cancer Terms

Insulin Receptor Substrate-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> Insulin Receptor Substrate-1

Insulin Receptor Substrate-1 Definition

The protein IRS1 acts as an interface between signaling proteins with Src homology-2 domains (SH2 proteins) and the receptors for insulin, IGF2, growth hormone, several interleukins (IL4, IL9, IL13), and other cytokines. It regulates gene expression and stimulates mitogenesis and appears to mediate insulin/IGF1-stimulated glucose transport. (from OMIM 600797)

Insulin Receptor Substrate-1 Synonyms

Insulin Receptor Substrate 1, IRS1

Terms in Insulin Receptor Substrate-1 category



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