Interferon Alpha Receptor Complex
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Interferon Alpha Receptor Complex Definition
Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)
Interferon Alpha Receptor Complex Synonyms
Interferon Alpha Receptor Complex, Interferon Alpha Receptor, Interferon Beta Receptor, Interferon-Alpha-Beta Receptor
Terms in Interferon Alpha Receptor Complex category
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