Interleukin-12-Receptor Beta-1-Chain
Cancer Terms ->
Gene Product ->
Protein ->
Protein Complex Subunit -> Interleukin-12-Receptor Beta-1-Chain
Interleukin-12-Receptor Beta-1-Chain Definition
Human IL12RB1 Gene (Type I Cytokine Receptor 2 Family) encodes 2 alternative isoforms of Interleukin 12 Receptor Beta 1 Chain, a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of I12RB1 and IL12RB2. IL12RB1 defects cause mycobacterial and Salmonella susceptibility. (NCI)
Interleukin-12-Receptor Beta-1-Chain Synonyms
Interleukin-12 Receptor Beta-1 Chain
Terms in Interleukin-12-Receptor Beta-1-Chain category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.