Interleukin-6 Signal Transducer
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Interleukin-6 Signal Transducer Definition
Widely expressed (not restricted to IL6 responsive cells) by human IL6ST Gene (Type I Cytokine Receptor 2 Family), heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer contains 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI)
Interleukin-6 Signal Transducer Synonyms
Interleukin 6 Signal Transducer, CD130 Antigen, IL6ST, Interleukin Receptor Beta Chain, Membrane Glycoprotein gp130, Oncostatin M Receptor, gp130 Transducer Chain
Terms in Interleukin-6 Signal Transducer category
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