Lexatumumab

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Agent -> Monoclonal Antibody -> Lexatumumab

Lexatumumab Definition

A fully human monoclonal agonistic antibody directed against tumor necrosis factor-alpha (TNF-alpha)-related apoptosis-inducing ligand receptor-2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural ligand TRAIL, lexatumumab binds to and activates TRAIL-R2, which may trigger apoptosis in and inhibit the growth of TRAIL-R2-expressing tumor cells. TRAIL-R2, also known as death receptor 5 (DR5), is a member of the TNF receptor family and is expressed on many malignant cell types.

Lexatumumab Synonyms

Lexatumumab, Anti-TRAIL Receptor 2 Monoclonal Antibody HGS-ETR2, HGS-ETR2, Monoclonal Antibody HGS-ETR2

Terms in Lexatumumab category

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