MAP-Kinase Interacting Kinase-1
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MAP-Kinase Interacting Kinase-1 Definition
Widely expressed by human MKNK1 Gene (Ser/Thr Kinase Family), alternative 465-aa (51-kDa) and 424-aa MAP Kinase Interacting Kinase 1 isoforms contain a typical Ser/Thr kinase domain, an N-terminal putative NLS, and share homology with MAPKAPK2, MAPKAPK3, and p90(RSK). Strongly interacting with, and phosphorylated/activated (via C-terminal region) by, dephosphorylated p38MAP and ERK kinases, but not JNK/SAPK, MKNK1 is activated by many extracellular mitogenic and stress stimuli. Docking with EIF4G1 and -2 C-terminal regions, MNK1 appears to regulate transcription by phosphorylating EIF4E and increasing affinity for the 7-methylG mRNA cap. MNK1 also interacts with the translational inhibitor p97 C- terminus. p97 may sequester MNK1, blocking eIF4E phosphorylation. (NCI)
MAP-Kinase Interacting Kinase-1 Synonyms
MAP Kinase Interacting Kinase 1, MAP Kinase-Interacting Serine/Threonine Kinase 1, MKNK1
Terms in MAP-Kinase Interacting Kinase-1 category
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