MCM Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Licensing Factor -> MCM Protein

MCM Protein Definition

The MCM proteins are essential replication initiation factors. The best known among them are a family of six structurally related proteins, MCM2-7, which are evolutionally conserved in all eukaryotes. The MCM2-7 proteins form a hexameric complex. This complex is a key component of the prereplication complex that assembles at replication origins during early G1 phase. The MCM2-7 proteins may be involved not only in the initiation but also in the elongation of DNA replication. Orchestration of the functional interactions between the MCM2-7 proteins and other components of the prereplication complex by cell cycle-dependent protein kinases results in initiation of DNA synthesis once every cell cycle. (from PMID 10872463 and NCI)

MCM Protein Synonyms

MCM Protein

Terms in MCM Protein category

DNA Replication Licensing Factor-MCM4
DNA Replication Licensing Factor-MCM5
DNA Replication Licensing Factor-MCM6
DNA Replication Licensing Factor-MCM7
Minichromosome Maintenance Protein-10
Minichromosome Maintenance Protein-2
Minichromosome Maintenance Protein-3