MED6 Homolog Protein
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MED6 Homolog Protein Definition
Encoded by human MED6 Gene (MED6 Family), 246-aa 28-kDa nuclear Mediator of RNA Polymerase II Transcription Subunit 6 Homolog is a coactivation component of transcriptional mediator complexes involved in transcriptional activation and repression. Transcription requires intermediary proteins that transduce signals from regulatory activator proteins to the basal transcription machinery at the core promoter. Physically associated with RNA polymerase II and essential for transcriptional activation, MED6 appears required for transcriptional activation of most of the RNA polymerase II-transcribed genes and not to be involved in uninduced or repressed transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I or III. MED6 is a subunit of the multiprotein ARC/DRIP and CRSP complexes. (NCI)
MED6 Homolog Protein Synonyms
Mediator of RNA Polymerase II Transcription Subunit 6 Homolog, ARC33, Activator-Recruited Cofactor 33 kDa Component, MED6 Homolog, NY-REN-28 Antigen, RNA Polymerase II Transcriptional Regulation Mediator
Terms in MED6 Homolog Protein category
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