MPC-6827
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Tubulin Binding Agent -> MPC-6827
MPC-6827 Definition
A quinazoline derivative with potential dual antineoplastic activities. MPC-6827 binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), MPC-6827 appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death.
MPC-6827 Synonyms
Microtubule Inhibitor MPC-6827, Azixa, MPC-6827
Terms in MPC-6827 category
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