Mapatumumab
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Mapatumumab Definition
A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities. TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis and reducing tumor growth.
Mapatumumab Synonyms
Mapatumumab, Anti-TRAIL R1-mAb, HGS-ETR1, TRM-1 mAb
Terms in Mapatumumab category
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