Cancer Terms

Melanocyte Development Pathway

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Melanocyte Development Pathway Definition

Studies with homozygous knockout mice have suggested that stem cell factor (SCF or KITLG), c-Kit, microphthalmia (Mitf), and B-cell CLL/lymphoma 2 (Bcl2) genes regulate melanocytic development. The SCF activation of Kit receptor leads to Mitf phosphorylation through the MAP kinase pathway. The activated Mitf recruits p300 and up-regulates Bcl2 transcription, which plays an important role in modulating the development and survival of the melanocyte lineage. (BioCarta)

Melanocyte Development Pathway Synonyms

Melanocyte Development Pathway, Melanocyte Development and Pigmentation Pathway

Terms in Melanocyte Development Pathway category



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