Monoclonal Antibody CD20
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Monoclonal Antibody CD20 Definition
An Fc-engineered monoclonal antibody directed against human CD20 with potential antineoplastic activity. Anti-CD20 monoclonal antibody AME 133v specifically binds to CD20 antigen (B1), preventing mitogen-induced B-cell proliferation; inhibiting B-cell differentiation; and promoting antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis of B cells expressing CD20. The Fc portion of this monoclonal antibody has been engineered to possess a higher binding affinity for variant Fc receptors on T helper cells, resulting in an augmentation of the anti-tumor immune response. Because of Fc engineering, this agent may be significantly more potent than rituximab in inducing B cell-directed ADCC. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B cells during most stages of B cell development.
Monoclonal Antibody CD20 Synonyms
Anti-CD20 Monoclonal Antibody AME-133v, AME-133v, LY 2469298, MoAb CD20, monoclonal antibody, CD20
Terms in Monoclonal Antibody CD20 category
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