Neuronal-SHC Adaptor Homolog Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> Neuronal-SHC Adaptor Homolog Protein

Neuronal-SHC Adaptor Homolog Protein Definition

Broadly expressed (highest in liver, pancreas, prostate, ovary, and brain) by human SLI Gene, 489-aa Neuronal SHC Adaptor Homolog contains a conserved N-terminal PTB domain, a CH domain, and a conserved C-terminal SH2 domain, as well as unique proline-rich motifs that may be SH3 recognition sites. SCK and NSHC mediate EGF signaling and both bind to neurotrophic receptors TRKA and TRKB. SCK appears to specifically associate with cytoplasmic c-SRC tyrosine kinase CSK (phosphorylated by SRC), which downregulates c-SRC kinase through C-terminal tyrosine phosphorylation. (NCI)

Neuronal-SHC Adaptor Homolog Protein Synonyms

SHC Transforming Protein 2, Neuronal SHC Adaptor Homolog, SCK, SHC-Like Protein SCK, SHC2, SHCB, SLI, Src Homology 2 Domain Containing Transforming Protein 2

Terms in Neuronal-SHC Adaptor Homolog Protein category

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