O 6 Benzylguanine
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O 6 Benzylguanine Definition
A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04)
O 6 Benzylguanine Synonyms
O6-Benzylguanine, 06-Benzyl Guanine, 06-Benzylguanine, 6-O-Benzylguanine, O(6)-Benzylguanine, O(6)-benzylguanine, O-6-Benzylguanine
Terms in O 6 Benzylguanine category
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