Oblimersen
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Oblimersen Definition
A phosphorothioate antisense oligonucleotide. Targeted to the initiation codon region of the bcl-2 mRNA, oblimersen inhibits bcl-2 mRNA translation, resulting in decreased expression of the bcl-2 protein, an apoptotic inhibitor expressed in some types of cancer and linked to tumor drug resistance. This agent may enhance the efficacy of standard cytotoxic chemotherapy. (NCI04)
Oblimersen Synonyms
Oblimersen, 5'-tct ccc agc gtg cgc cat, OBLIMERSEN, oblimersen, olbimersen
Terms in Oblimersen category
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